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Eating beforehand does not improve effectiveness or reduce side effects

Beyond neurological implications, the research extends to oncology, particularly tumors harboring mutations in the KEAP1 gene

The proposed mechanism most often cited involves GIP-receptor-mediated effects on adipose insulin sensitivity and possibly on central energy balance, though attribution between the two receptors in vivo remains an area of ongoing study

Its not just uncomfortableit can cause other problems too, like haemorrhoids, anal fissures, and even something called faecal impaction, which can make your stomach hurt and feel bloated

But if on a GLP-1, women need to actively NOT try to get pregnant because GLP-1s because these drugs are not known yet to be safe for pregnancy